Imipramine solubility-pH profiles: self-aggregation vs. common-ion effect

These findings, along with our previous solubility studies of desipramine and nortriptyline, suggest that even subtle structural variations can lead to significant differences in the aqueous media behaviour of tricyclic antidepressants. This type of information can be valuable in the early stages of drug discovery, in formulation optimization experiments, as well as in <i>in vitro</i> and <i>in vivo</i> studies.