Search for a command to run...
Background: Chordomas, rare tumors originating from residual chordate tissues, were first discovered in 1846. Predominantly affecting the base of the skull and the axial skeleton, these tumors are considered uncommon cancers. This systematic review will investigate the anatomical aspects and neurosurgical treatment modalities of skull base and spinal chordomas through a comprehensive analysis of available literature. Methods: We conducted a systematic literature review, adhering to PRISMA guidelines, by searching Databases including Web of Science, PubMed/Medline, EMBASE, Google Scholar, and Cochrane Library using specific keywords such as "chordomas," "skull base," "skull base anatomy," "spinal/sacral chordoma surgery," and "adjuvant therapy." Data analysis was performed using Microsoft Excel and SPSS Statistics for Windows, version 26.0 (IBM Corp., Armonk, NY, USA). And R software. Results: In this study, we conducted an intensive systematic review and meta-analysis, including a total of N=2,083 patients with clinical and neurological manifestations, as outlined between Table I and Table IV. The analysis yielded N=1,485, (71.5%) patients, N=636,GTR, N=640, STR N=568, Radiotherapy, as detailed in Tables I and II and Figures 1, 2, and 3. Heterogeneity was assessed as follows: Chi² = 18.41, df = 14, P < 0.19 vs. I² = 24%, test for overall effect: Z = 1.25, P = 0.21. Conclusion: The aggressive nature of chordomas necessitates personalized treatment strategies. Surgical approaches, particularly for elderly patients, proved promising in chordoma excision. Despite advancements, further research into disease management and etiopathogenesis is crucial for improved prevention, detection, and treatment strategies. Adjuvant therapies exhibited enhanced survival rates, highlighting their significance in prolonging patients' lives post-surgery.