Modulation of the Apolipoprotein M/S1PR4 Pathway Reduces Podocyte Lipid Overload in Alport Syndrome via Distinct Autophagy and Efflux Mechanisms

20251 citationsJournal Article

Authors

Matthew Tolerico · University of Miami

Judith Molina · University of Miami

Arianna Insenga · University of Miami

Arianna Carrazco · University of Miami

Rachel Njeim · University of Miami

Alexis Sloan · University of Miami

Anthony J. Griswold · University of Miami

Abstract

We found that the APOM/S1P axis was dysregulated in Col4a3-/- podocytes. Targeting this pathway through APOM supplementation or S1P receptor 4 antagonism improved kidney function and reduced lipid accumulation by enhancing either cholesterol efflux or autophagy, respectively.

Topics & Keywords

Renal Diseases and Glomerulopathies Lymphatic System and Diseases Genetic and Kidney Cyst Diseases

Publication Details

Published in: Journal of the American Society of Nephrology

DOI: 10.1681/asn.0000000996

Field-Weighted Citation Impact: 1.43

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Modulation of the Apolipoprotein M/S1PR4 Pathway Reduces Podocyte Lipid Overload in Alport Syndrome via Distinct Autophagy and Efflux Mechanisms

Authors

Abstract

Topics & Keywords

Publication Details