Molecular profiling of chemotherapy-resistant breast cancer reveals DNA methylation remodeling associated with the acquisition of paclitaxel resistance

20260 citationsJournal Articlehybrid Open Access

Authors

Lenka Trnkova · Biomedical Research Center of the Slovak Academy of Sciences

Monika Buríková · Institute of Chemistry of the Slovak Academy of Sciences

Andrea Šoltýsová · Slovak Academy of Sciences

Andrej Ficek · Comenius University Bratislava

Jana Plavá · Institute of Chemistry of the Slovak Academy of Sciences

Andrea Čumová · Institute of Chemistry of the Slovak Academy of Sciences

Abstract

Chemoresistance in BC involves extensive genomic and epigenetic remodeling. Although DAC can modulate methylation and tumor phenotype, rational drug combinations will be required to overcome resistance.

Topics & Keywords

Epigenetics and DNA Methylation Breast Cancer Treatment Studies Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Drug Resistance Updates

Volume 85, pp. 101350-101350

DOI: 10.1016/j.drup.2026.101350

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