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Ageing is often framed as near-linear accumulation of cell-intrinsic lesions, yet late-life mortality risk accelerates exponentially following the Gompertz law. Furthermore, systemic interventions—including therapeutic plasma exchange and extracellular-vesicle-based therapies—and the transient embryonic rejuvenation phase can induce rapid, broadly coordinated organism-wide rejuvenation on timescales difficult to attribute to gradual repair alone, consistent with strong leverage via systemic coupling fields. Here, we propose an integrative-first hierarchical framework in which primary lesions provide slow inputs, while organism-level signalling networks—intercellular communication and senescence-associated signalling—can transition into a self-amplifying regime that acts as a supralinear amplifier and imposes late-life acceleration. This architecture provides a mechanistic basis for both the embryonic biological-age reset and Gompertzian late-life acceleration by positioning organism-level coupling as the central control parameter governing ageing trajectories. It further implies regime-dependent therapeutic leverage: cell-autonomous approaches are most effective as early-life prevention and can slow progression midlife, whereas durable late-life reversal requires a systemic signalling reset that suppresses amplification and restores buffering capacity. By framing rejuvenation as a global state change, the framework positions cell-autonomous strategies, including partial reprogramming, as most effective when coupled to a rejuvenated systemic milieu, charting a roadmap for coordinated reversal.