Thalamic responsive neurostimulation signals and seizure semiology in pediatric patients

This study demonstrates that seizure onset EEG signals are nucleus- and semiology-specific in pediatric patients receiving thalamic RNS therapy. These findings highlight the CM nucleus's central role in seizure propagation and support individualized RNS programming based on EEG frequency signatures. While limited by sample size, this work provides early evidence that thalamic EEG biomarkers can inform more precise neuromodulation strategies for pediatric DRE.