Inflammatory markers (IL-6 and CRP) in childhood and their association with brain structure and psychotic experiences in adulthood

These findings suggest that individuals who go on to develop PEs were more vulnerable to the effects of circulating CRP on grey matter volume, consistent with a possible disease-specific pathway linking inflammation to psychosis. In contrast, IL-6 was associated with smaller volume in regions of the default mode network regardless of PEs, suggesting a more general effect on brain development.