Metformin and CoQ10 combination therapy: a novel approach to mitigating ischemia-reperfusion injury and cognitive impairment

20260 citationsJournal Article

Authors

Avinash Singh Mandloi · SCMS Group of Educational Institutions

Vivek Kumar Sinha · SCMS Group of Educational Institutions

Chandrashekhar Upasani · SCMS Group of Educational Institutions

Vipin Dhote · SCMS Group of Educational Institutions

Aman B. Upaganlawar · SCMS Group of Educational Institutions

Abstract

Co-administration of MT and CQ offered enhanced neuroprotection compared to individual treatments. This benefit may stem from additive or synergistic antioxidant effects and AMPK activation, suggesting potential for combined therapy in ischemic stroke management.

Topics & Keywords

Coenzyme Q10 studies and effects Mitochondrial Function and Pathology GDF15 and Related Biomarkers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Brain Injury

Volume 40, Issue 4, pp. 238-249

DOI: 10.1080/02699052.2025.2612032

Field-Weighted Citation Impact: 0.00