Parkin–ACSL4 axis in ferroptosis regulation: a narrative review on therapeutic insights from exercise in aging cardiomyocytes

20260 citationsJournal Articlediamond Open Access

Authors

Behnam Bagherzadeh-Rahmani · Technical and Vocational University

Raheleh Rezaali · Islamic Azad University Central Tehran Branch

Brent R. Stockwell · Columbia University

Abstract

Ferroptosis, iron-dependent regulated cell death, drives age-related cardiac dysfunction. This review examines aerobic exercise modulation of ferroptosis in aging cardiomyocytes via Parkin-ACSL4 axis. Parkin promotes ACSL4 ubiquitination/degradation, reducing lipid peroxidation and ROS. Exercise activates PINK1/Parkin mitophagy and hepcidin, enhancing mitochondrial resilience and iron homeostasis. Despite promising preclinical evidence, molecular mechanisms remain unclear. Aerobic exercise offers non-pharmacological cardiac protection against ferroptosis in aging.

Topics & Keywords

Ferroptosis and cancer prognosis Autophagy in Disease and Therapy Cardiovascular Health and Risk Factors

Publication Details

Published in: npj Metabolic Health and Disease

Volume 4, Issue 1, pp. 1-1

DOI: 10.1038/s44324-025-00092-z

Field-Weighted Citation Impact: 0.00

Command Palette

Parkin–ACSL4 axis in ferroptosis regulation: a narrative review on therapeutic insights from exercise in aging cardiomyocytes

Authors

Abstract

Topics & Keywords

Publication Details