A low-calorie rebaudioside D–glucose–sodium sweetener matches sucrose in palatability and neural responses in a functional MRI study of healthy adults

The RebD mix matched sucrose in subjective palatability and OFC responses, while removal of Na⁺ altered OFC- postcentral gyrus connectivity linked to satiety. These findings indicate that the RebD mix, a novel low-calorie formulation, may achieve sucrose-comparable palatability.