Investigating the neuroprotective effect of heparin in improving mitochondrial function in rats with cardiac arrest cardiopulmonary resuscitation based on transcriptome sequencing

Heparin provided neuroprotection after CA-CPR by ameliorating mitochondrial dysfunction via multi-target regulation of key genes (Epsa1, Idh2, and Hif3a), enhancing energy metabolism, reducing oxidative stress, and inhibiting hyperactivated coagulation-inflammation cascades. These findings highlight heparin's potential as an adjunctive therapy for improving neurological outcomes post-resuscitation.