Skin pharmacokinetics and pharmacodynamics in patients with post-kala-azar dermal leishmaniasis

20261 citationsJournal Articlehybrid Open Access

Authors

Wan-Yu Chu · Ludwig Cancer Research

Om Prakash Singh · Banaras Hindu University

Shyam Sundar · Banaras Hindu University

Krishna Kumar Pandey · Rajendra Memorial Research Institute of Medical Sciences

Pradeep Das · National Institute of Research in Tuberculosis

Dinesh Mondal · International Centre for Diarrhoeal Disease Research

Brima M. Younis

Abstract

Similar skin PK target attainment and relative parasite reduction were achieved for all regimens. Regional differences in parasite load and lesion score at baseline and lesion healing rates, suggest disease presentation is the primary factor affecting clinical outcomes.

Topics & Keywords

Research on Leishmaniasis Studies Phenothiazines and Benzothiazines Synthesis and Activities Eosinophilic Disorders and Syndromes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: International Journal of Antimicrobial Agents

Volume 67, Issue 3, pp. 107713-107713

DOI: 10.1016/j.ijantimicag.2026.107713

Field-Weighted Citation Impact: 41.59