Perampanel Blocks Transsynaptic α‐Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease

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Authors

Jun Ueda · Kyoto University

Norihito Uemura · Kyoto University

Jiarui Chang · Kyoto University

Tetsuya Hirato · Kyoto University

Tomoyuki Ishimoto · Kyoto University

Miki Oono · Kyoto University

Shuichi Matsuzawa · Kyoto University

Abstract

Perampanel could be a disease-modifying drug for Lewy body disease that modulates transsynaptic α-synuclein propagation, presumably by suppressing dynamin-dependent endocytosis. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Neurogenesis and neuroplasticity mechanisms

Publication Details

Published in: Movement Disorders

DOI: 10.1002/mds.70191

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Perampanel Blocks Transsynaptic α‐Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease

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Abstract

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Publication Details