MAPK-related mRNA and miRNA Expression in LPS-treatedKeratinocytes: Implications for Psoriasis Inflammation

20260 citationsJournal Article

Authors

Aleksandra Plata-Babula · WSB University

Michał Wójcik · WSB University

Amelia Głowaczewska · Państwowa Wyższa Szkoła Zawodowa w Nysie

nikola zmarzły · WSB University

Michał Chalcarz · WSB University

Konrad Kaminiów · WSB University

Elżbieta Mitka-Krysiak ·

Abstract

LPS stimulation alters MAPK-related mRNA and protein expression in HaCaT cells and is accompanied by changes in specific regulatory miRNAs. This integrative transcriptomic- proteomic analysis highlights candidate miRNA-mRNA axes relevant to psoriasis pathophysiology and supports further validation in disease-relevant models.

Topics & Keywords

Psoriasis: Treatment and Pathogenesis NF-κB Signaling Pathways Melanoma and MAPK Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Current Pharmaceutical Biotechnology

Volume 27

DOI: 10.2174/0113892010379048251031100323

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