Longitudinal metabolomics study of phosphate‐adenine‐guanosine‐glucose‐saline‐mannitol stored red blood cells

This study highlights the impact of storage-induced metabolic changes in exacerbating transfusion-related complications. Therefore, optimization of additive solutions, such as stabilizing methionine levels during storage, may mitigate storage lesions and improve outcomes. Additionally, the storage-time-related increase in mast cell activation suggests a need for targeted interventions, particularly for patients vulnerable to ATRs.