30 Years of Enamel Matrix Derivative ( <scp>EMD</scp> ): Biological Foundations and Systematic Review With Meta‐Analyses Across Multiple Clinical Indications

EMD is one of the few biological agents with human histologic evidence supporting periodontal regeneration. This is reflected in improved clinical outcomes when used in regenerative surgery for intrabony defects. Despite its biological plausibility for broader therapeutic applications, further high-quality randomized clinical trials are needed to better define its role in nonsurgical treatment of periodontitis, root coverage procedures, and regenerative surgery of furcation involvement. Future research should also focus on optimizing application protocols and exploring novel combinations with other regenerative biomaterials.