Plasma proteome‐wide analysis of dementia risk mechanistically implicates synaptic biomarkers

20250 citationsJournal Articlehybrid Open Access

Authors

Keenan A. Walker · National Institutes of Health

JINGSHA CHEN · Johns Hopkins University

Shi Liu · Heptares Therapeutics (United Kingdom)

Yunju Yang · The University of Texas Health Science Center at Houston

Myriam Fornage · Brown Foundation

Linda Zhou · Johns Hopkins University

Pascal Schlosser

Abstract

These results suggest that synaptic proteins are released from the CNS into the blood well before symptom onset. Synaptic proteins measured in blood, such as CPLX1, may represent mechanistically relevant biomarkers of AD dementia risk.

Topics & Keywords

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Advanced Proteomics Techniques and Applications

Publication Details

Published in: Alzheimer s & Dementia

Volume 21, Issue S2, pp. e105743-e105743

DOI: 10.1002/alz70856_105743

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Plasma proteome‐wide analysis of dementia risk mechanistically implicates synaptic biomarkers

Authors

Abstract

Topics & Keywords

Publication Details