Very Early Biologic Therapy within Six Months of Crohn’s Disease Diagnosis Improves One-Year Steroid-Free Clinical Remission: A Retrospective Cohort Study

Initiating biologic therapy within 6 months of CD diagnosis significantly increases 1-year steroid-free clinical remission and reduces corticosteroid dependence compared with initiation at 6-24 months. These real-world data support adopting a standardized "very early" biologic treatment strategy to optimize clinical outcomes in newly diagnosed, biologic-naïve CD.