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For many entrepreneurs, the terms "supercomputers" or "High-Performance Computing" are primarily associated with academic institutions, theoretical research, or complex graphs understood only by a small group of experts. Some may also link them with services offered by Google or Amazon to businesses, but "available only to those with large budgets." This publication aims to demonstrate that supercomputers are increasingly becoming a part of the business landscape, and not necessarily just for the big companies. Small and medium-sized enterprises (SMEs), as well as startups, can successfully benefit from them. By combining a clear explanation of supercomputer capabilities with real-life case studies, the article aims to convince entrepreneurs that HPC is no longer a niche technology, but a real game-changer for SMEs across diverse sectors of the economy. We will discuss: • how the use of supercomputers can create a unique value proposition and expand the customer base, • how machine learning and generative AI can scale up business, • the path to financing access to supercomputers in Europe. In this paper, we will present two paths for applying for grants: one for entrepreneurs with no prior experience in HPC, and another for those looking to use supercomputers at a more advanced level. We will also provide essential information on the application process, key participation requirements, and the grant application schedule.