Association between plasma glucosylsphingosine levels and dyskinesia burden in GBA1-related Parkinson's disease

20260 citationsJournal Articlegold Open Access

Authors

Massimo Marano · Campus Bio Medico University Hospital

Carmela Zizzo · Institute for Biomedical Research and Innovation

Francesco Cavallieri · Azienda Sanitaria Unità Locale di Reggio Emilia

Micol Avenali · University of Pavia

Tommaso Schirinzi · University of Rome Tor Vergata

Edoardo Monfrini · Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Francesca Spagnolo

Abstract

This study reveals an association between GlcSph and dyskinesias in GBA1-PD, that should prompt further investigation to assess the GlcSph role as a possible biomarker and target to tackle dyskinesias in GBA1-PD.

Topics & Keywords

Sphingolipid Metabolism and Signaling Lysosomal Storage Disorders Research Glycosylation and Glycoproteins Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurobiology of Disease

Volume 219, pp. 107271-107271

DOI: 10.1016/j.nbd.2026.107271

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