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Background: Foodware and food packaging materials are a source of human exposure to chemicals because chemicals migrate from food contact materials (FCMs) into foodstuffs. Some of the migrating food contact chemicals (FCCs), such as bisphenols and phthalates, are regularly discussed and receive regulatory attention due to their known hazards, such as endocrine disruption, carcinogenicity, and reproductive toxicity. However, so far no systematic approach has been employed to identify and prioritize all known FCCs. Methodology: The FCCprio List was compiled in order to systematically identify and prioritize FCCs based on their hazards and exposure potential. The list was created following the published, evidence-based method established by the PlastChem project. The method was slightly modified to include only harmonized GHS-aligned hazard classifications with a focus on human health hazards. Specifically, publicly available and officially recognized hazard information was collected for all known FCCs. On the basis of these data, FCCs were prioritized if they have at least one of the following hazards: persistence, bioaccumulation, mobility, carcinogenicity, mutagenicity, reproductive toxicity, specific target organ toxicity upon repeated exposure, and/or endocrine disruption. The prioritized FCCs were subsequently ranked into four tiers based on their evidence for human exposure via FCMs, as reported in the FCChumon, FCCmigex and FCCdb databases. Details can be found in the 'FCCprio: Methodology' document provided in this repository. Summary results: In total, 1’222 FCCs were identified as hazardous and placed on the FCCprio List and ranked based on their relevance for human exposure from FCMs. Tiers 1 to 4 contain 94, 264, 224, and 640 FCCs, respectively (Figure 2). Tier 1 chemicals, which have the highest evidence for human exposure from FCMs, include, for example, ortho-phthalates, metals and metalloids, per- and polyfluoroalkyl substances (PFASs). Furthermore, 142 FCCs might be of concern due to a lower hazard category (e.g., Carc. 2), and 252 FCCs due to their environmental hazards (i.e., Aquatic Chronic 1 or 2). Of the 15’159 known FCCs, 13’211 (87%) currently lack any relevant hazard data and could thus not be prioritized. When additionally hazard data from the ECHA notified C&L inventory are considered (download date: 2024-Jul-23) [12], another 769 potentially hazardous FCCS can be identified. Detailed results and all chemicals on the FCCprio List can be found in the 'FCCprio List' Excel file provided in this repository. Periodic future updates will be made to the FCCprio List as new scientific information becomes available. These updates will be added to this repository under separate version numbers.