Assessment of Toxicity in the Extract of the Herb Betonica

The acute, subacute and chronic toxicity of an extract from the herb Betonica officinalis in laboratory rats was studied. Acute toxicity: LD50 > 5000 mg/kg (orally). Subacute (28 days, upto 2000 mg/kg) and chronic (180 days, up to 900 mg/kg) toxicity: no significant changes in general condition, hematological, biochemical parameters and pathomorphological changes were detected. Conclusion: Medicinal letter letter extract is non-toxic and promising for further pharmacological studies.