Destabilization of cardiac myosin acetylation and sequestration with type 2 diabetes mellitus

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Authors

Mahault Mathilde Degezelle · University of Copenhagen

Chahida Chaami · University of Copenhagen

Christopher T. A. Lewis · University of Copenhagen

Chengxin Zhang · University of Michigan

Anthony L. Hessel · Ophthalmic Consultants of Boston

P. Rainer · Medical University of Graz

Jonathan A. Kirk

Abstract

Human T2DM myocardium exhibits early, site‑specific myosin acetylations that destabilize myosin structural OFF‑state. This myosin 'preload' remodeling occurs at no energetic cost and may constitute a potential early marker of latent myocardial vulnerability in T2DM.

Topics & Keywords

Cardiac Structural Anomalies and Repair Cardiovascular Function and Risk Factors Cardiomyopathy and Myosin Studies

Publication Details

Published in: Cardiovascular Diabetology

Volume 25, Issue 1

DOI: 10.1186/s12933-025-03052-5

Field-Weighted Citation Impact: 0.00

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Destabilization of cardiac myosin acetylation and sequestration with type 2 diabetes mellitus

Authors

Abstract

Topics & Keywords

Publication Details