Two Pediatric Cases of Kimura Disease Following Vaccination

Kimura disease is a chronic inflammatory disorder characterized by peripheral eosinophilia, elevated serum IgE levels, and a painless mass. Although it predominantly affects adult males, pediatric cases have also been reported. We report two pediatric cases of Kimura disease diagnosed after adverse events following vaccination, presenting with swollen lymph nodes of the neck and upper limbs. Since children are vaccinated more often than adults, a painless mass following vaccination may constitute an important clinical clue in the diagnosis of Kimura disease. Attention should be paid to the differentiation between Kimura disease and immunoglobulin G4-related disease (IgG4-RD) owing to its similarities. This report provides valuable insights into the link between vaccination and Kimura disease, and emphasizes the importance of early diagnosis, especially in children, to ensure timely treatment and appropriate management.