Aberrant systemic acute-phase complement responses in conjunction with soluble CR1 attribute to varying grades of dengue disease severity

Our findings show that aberrant complement activation and levels of sCR1 could attribute to varying grades of dengue severity. Given its inverse association, the levels of sCR1 could likely render early prediction of dengue disease severity. The role of sCR1 in complement-mediated pathogenesis in dengue remains a gray area of investigation.