The differential effects of CBD and CBDA on viability and mRNA expression in colorectal cancer cells

20260 citationsJournal Articlegold Open Access

Authors

Christine Heinzle · Vorarlberg Institute for Vascular Investigation and Treatment

Kathrin Geiger · Vorarlberg Institute for Vascular Investigation and Treatment

Reinhard Ertl · University of Veterinary Medicine Vienna

Eva Maria Brandtner · Vorarlberg Institute for Vascular Investigation and Treatment

Andreas Leiherer · Private University in the Principality of Liechtenstein

Stella Gaenger · Vorarlberg Institute for Vascular Investigation and Treatment

Abstract

Our findings showed that CBD exerts stronger effects on cell survival and gene expression in CRC cells than CBDA, which showed only limited activity. Moreover, the CBDA-rich C.s. extract exhibited greater efficacy than the CBDA/CBD mixture. More research is needed to further elucidate the impact of cannabinoids on CRC cell biology and signaling pathways.

Topics & Keywords

Cannabis and Cannabinoid Research Genomics, phytochemicals, and oxidative stress Hops Chemistry and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Cannabis Research

Volume 8, Issue 1, pp. 24-24

DOI: 10.1186/s42238-026-00391-2

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