Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau proteolysis

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Authors

Caroline Ackley · University Memory and Aging Center

Zoe Liau · University of California, San Francisco

Shruti Arya · University Memory and Aging Center

Tara Antee · University of California, San Francisco

Emily Cheang · University Memory and Aging Center

Giselle M. Knudsen · Profectus Biosciences (United States)

Lane-Donovan Courtney

Abstract

Collectively, these results underscore the importance of lysosomal processing of APP, identify a link between APP and tau, and suggest new avenues for exploring AD pathogenesis. They also highlight potential therapeutic targets related to the lysosomal function of APP and its impact on neurodegenerative diseases.

Topics & Keywords

Alzheimer's disease research and treatments Cellular transport and secretion Lysosomal Storage Disorders Research

Publication Details

Published in: Molecular Neurodegeneration Advances

Volume 2, Issue 1, pp. 10-10

DOI: 10.1186/s44477-025-00017-6

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Lysosomal protease-mediated APP degradation is pH-dependent, mutation-sensitive, and facilitates tau proteolysis

Authors

Abstract

Topics & Keywords

Publication Details