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Excerpt from the Executive Summary: Deliverable D5.3 - Initial Data Management Plan (DMP) is a formal statement describing how research data will be managed and documented throughout the research project and the terms regarding the subsequent deposit of the data with a data repository for long-term management and preservation. Beneficiary Pintail is responsible for D5.3 as part of Work Package 5 (WP5), which has four objectives and is broadly responsible for Management, Communication, Dissemination and Exploitation. PHOENIX will develop and validate a new immunotherapy for transplant medicine that prevents graft rejection and induces transplant tolerance, without compromising normal immunity to infections and cancer. PHOENIX aims to pre-clinically validate this new approach in transplants of two organs (kidney and liver) in two animal species (mice and pigs), to provide robust evidence for future clinical trials. A new data output of PHOENIX will be shared experimental data, including laboratory research (phenotype, immunological function, transcriptomic, sex, weight, age, etc.) data collected in our planned murine and porcine studies and analysed in PHOENIX to assess the efficacy of the new nanomedicines. PHOENIX will also produce data such as specifications for the pMHC-NP nanoparticle production, experimental protocols, and single cell transcriptomic data. Data will be prepared and submitted in a form to facilitate re-use, complying entirely with the FAIR principles. PHOENIX will also re-use data, comparing PHOENIX data, for example, with existing datasets in Single-cell RNA sequencing (scRNAseq) from previous research.