Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

20261 citationsJournal Articlehybrid Open Access

Authors

Marco De Martino · University of Naples Federico II

Matteo Lampitto · University of Rome Tor Vergata

Alfredo Fusco · University of Naples Federico II

Marco Barchi · University of Rome Tor Vergata

Francesco Esposito · Institute for Experimental Endocrinology and Oncology

Paolo Chieffi · University of Campania "Luigi Vanvitelli"

Abstract

Our results indicate a role of HMGA2 in the EC, because its inhibition reduces cell malignant characteristics, and may represent a viable therapeutic target to improve the prognosis of CisR TGCTs.

Topics & Keywords

Genomics and Chromatin Dynamics Clusterin in disease pathology Epigenetics and DNA Methylation

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Andrology

DOI: 10.1111/andr.70177

Field-Weighted Citation Impact: 23.00