Nonsurgical Aesthetic Treatment of the Face and Neck in GLP-1 Receptor Agonist Weight Loss Patients: Experience-Based Considerations

Glucagon-like peptide-1 (GLP-1)-based therapies are increasingly used to support weight loss. However, there can be significant sequelae with regard to the aesthetics of the face and neck, including midface volume loss; temple, infraorbital, and submalar hollowing; increased skin laxity; accentuation of wrinkles and folds; and worsened skin quality. Individuals seeking nonsurgical correction of these issues are likely to become increasingly common, but treatments have not yet been widely studied in this population. The aim of this paper is to provide experience-based guidance on multimodal nonsurgical aesthetic treatment of the face and neck in patients undergoing weight loss with GLP-1-based therapies. Four clinicians with extensive experience of this patient group completed a written questionnaire and were individually interviewed. Their joint knowledge and expertise form the basis of this guidance. In addition, a PubMed literature search was conducted up to March 31, 2025. Eligibility for nonsurgical modalities does not typically differ greatly in this group compared with other aesthetic patients, but consideration should be given to the optimal timing of treatment within the weight loss journey. Multimodal approaches are usually needed based on volumizing with hyaluronic acid fillers; skin tightening with collagen-stimulating methods (such as energy-based devices); reduction of wrinkles and banding (particularly in the lower face and neck); and other skin quality treatments. Regular follow-up is crucial for tracking outcomes and evaluating evolving aesthetic needs. Holistic management should incorporate detailed patient education and ongoing nutritional, lifestyle, and psychological support. By following these principles, good aesthetic outcomes can be achieved. <b>Level of Evidence</b>: 5 (Therapeutic).