The Clinico-Epidemiological Profile and Effectiveness of Codeine and Triprolidine in Dry Cough Patients Not Responding to Non-Opioid-Based Antitussives: Results From a Prospective, Multicenter, Single-Arm, Open-Label Postmarketing Observational Study

In this observational study of 250 adults with dry cough, balanced by gender and predominantly middle-aged with a mean age 40.8 years, the FDC of codeine phosphate 10 mg and triprolidine HCl 1.25 mg per 5 mL oral syrup, prescribed as 10 mL thrice daily for seven days, significantly reduced cough severity, frequency, and nighttime awakenings, improving the QoL. Importantly, these results support the role of this FDC in the management of dry cough, especially when non-opioid antitussives are ineffective, a key differentiator of this study. Benefits were consistent across different etiologies of dry cough, with only mild, non-serious adverse events.