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Purpose: Aging and hormonal factors influence meibomian gland dysfunction (MGD), which can be treated by intense pulsed light (IPL) therapy. However, the influence of age on treatment response remains unclear. This study aimed to investigate the impact of aging on the outcomes of IPL therapy among female patients with MGD. Patients and Methods: Sixty-eight eyes of female patients who underwent four IPL treatment sessions were included. Patients were divided into two age groups: < 50 years (39.5 ± 10.2 years, n = 30) and ≥ 50 years (72.5 ± 9.49 years, n = 38). Parameters assessed before and after IPL included corneal and conjunctival staining score, fluorescein tear film break-up time (FBUT), lipid layer thickness (LLT), subjective symptoms (Standard Patient Evaluation of Eye Dryness [SPEED] score), and meibomian gland parameters (meibum quality, expressibility, and meiboscore). Statistical analyses were performed using the Mann–Whitney U and Wilcoxon signed-rank tests; p < 0.05 indicated statistical significance. Results: At baseline, the younger group had lower LLT ( p < 0.01) and poorer expressibility ( p = 0.049) than did the older group, who showed worse corneal and conjunctival staining score ( p = 0.04) and meiboscore ( p < 0.01). After treatment, the younger group exhibited significant improvements in FBUT, LLT, meibum quality, expressibility, meiboscore, and SPEED scores, whereas the older group showed significant improvement in corneal and conjunctival staining scores, FBUT, expressibility, and SPEED scores. Between-group comparisons showed greater improvements in meibum quality and expressibility in the younger group (both p < 0.01), while improvement in corneal and conjunctival staining score was greater in the older group ( p = 0.02). Conclusion: IPL therapy improved MGD-related signs and symptoms in women of all ages. The observed age-related differences in the most responsive parameters suggest that age affects the therapeutic profile of IPL. These results may help guide age-appropriate MGD management. Keywords: meibomian gland dysfunction, intense pulsed light, lipid layer thickness, standard patient evaluation of eye dryness score, age-related differences