Overcoming Ceftaroline Resistance in MRSA Using Ceftaroline–Carbapenem Combination Therapy

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Authors

J. Olson · University of California, Irvine

Alaguvel Valliammai · University of California, Irvine

Gabriel Pérez-Parra · University of California, Irvine

Allen Jankeel · University of California, Irvine

Anuj K Khetarpal · University of California, Irvine

Valeria Rodríguez-Guevara · University of California, Irvine

Vanessa Vu

Abstract

The limited but rising threat of ceftaroline-resistant MRSA poses a therapeutic challenge. We show that ceftaroline plus carbapenems restores activity against a resistant strain both in vitro and in a murine bacteremia model. These findings support combination therapy as a potential strategy for difficult MRSA infections, warranting further clinical investigation.

Topics & Keywords

Antimicrobial Resistance in Staphylococcus Antibiotic Resistance in Bacteria Bacterial Infections and Vaccines

Publication Details

Published in: Open Forum Infectious Diseases

Volume 13, Issue 1, pp. ofag009-ofag009

DOI: 10.1093/ofid/ofag009

Field-Weighted Citation Impact: 0.00

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Overcoming Ceftaroline Resistance in MRSA Using Ceftaroline–Carbapenem Combination Therapy

Authors

Abstract

Topics & Keywords

Publication Details