Activity of novel antibiotics against dual metallo-Beta-lactamase producing <i>Enterobacter hormaechei</i> clinical isolates

20250 citationsJournal Articlegold Open Access

Authors

Camila Solar · Universidad del Desarrollo

Lorena Díaz · Millennium Initiative for Collaborative Research on Bacterial Resistance

Katherine Soto · Millennium Initiative for Collaborative Research on Bacterial Resistance

Jose R W Martínez · Universidad del Desarrollo

Nicolás Canales · Universidad Andrés Bello

Yehudit Bergman · Johns Hopkins Medicine

Anne Peters

Abstract

Our findings indicate that <i>E. hormaechei</i> clinical isolates co-producing NDM and VIM metallo-carbapenemases exhibited susceptibility to all tested novel BL/BLIs, including aztreonam/avibactam, cefepime/taniborbactam and cefepime/zidebactam. The combination of cefiderocol and xeruborbactam restored the activity of cefiderocol.

Topics & Keywords

Antibiotic Resistance in Bacteria Antibiotics Pharmacokinetics and Efficacy Nosocomial Infections in ICU

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAC-Antimicrobial Resistance

Volume 8, Issue 1, pp. dlaf252-dlaf252

DOI: 10.1093/jacamr/dlaf252

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