Bilateral Peripheral Neovascularization in Hemoglobin C Trait Retinopathy

<b>Purpose:</b> To describe a case of bilateral peripheral neovascularization (NV) secondary to hemoglobin C trait. Method: A single case was evaluated. Results: A 74-year-old African American woman presented asymptomatically with peripheral nonperfusion and NV on examination and angiography during an anemia evaluation, which led to a diagnosis of hemoglobin C trait. <b>Conclusion:</b> Hemoglobin C trait is a rare but known cause of NV. This case highlights the importance of hemoglobinopathy screening in cases of peripheral NV, as these findings may indicate systemic disease and require a multidisciplinary approach.