Effects of estradiol, tamoxifen, and raloxifene on human temporal lobe cortex astroglial cell spreading

20260 citationsJournal Articlediamond Open Access

Authors

Ivaldo Silva · Indiana University Bloomington

Frederick Naftolin · United BioSource Corporation (United Kingdom)

Vinicius Oliveira Santana · Universidade Federal de São Paulo

Anne Williamson · Yale University

Ahmed Fadiel · University of Chicago

Spencer Dd · Yale University

Howard J. Li

Abstract

Estradiol, tamoxifen, and raloxifene - widely used hormonal agents - were associated with distinct effects on astrocyte morphology in human cortical tissue. These findings support a role for estrogen receptor modulation in astroglial structural regulation and suggest a potential cellular mechanism contributing to central nervous system symptoms reported in clinical settings.

Topics & Keywords

Menopause: Health Impacts and Treatments Neuroscience and Neuropharmacology Research Cancer-related cognitive impairment studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gynecological Endocrinology

Volume 42, Issue 1, pp. 2618881-2618881

DOI: 10.1080/09513590.2026.2618881

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