Povidone-iodine capabilities in the local therapy of urogenital infectious and inflammatory diseases

Background. Povidone-iodine is a water – soluble iodine formulation with antimicrobial effect against a wide range of microorganisms (bacteria, fungi, protozoa, viruses). No acquired microbial resistance has been reported for povidone-iodine over the decades of its use due to its multiple-targeted action. Povidone-iodine has been used for a long time in surgical, gynecological and dermatological practice; it is highly effective in different forms and concentrations and retains its antimicrobial activity even when diluted 1:100 or more. Due to the high safety profile of lower concentration povidone-iodine solutions (while maintaining their effectiveness), they can also be used on the skin and mucous membranes of the genitourinary system, so these solutions may be considered as a promising addition to the main therapy (or in some cases as a variant of the main therapy) of bacterial vaginosis or sexually transmitted infections. Conclusion. The range of povidone-iodine formulations is registered in the Russian Federation in the form of a 10.0% ointment and a 7.5% solution; it has a declared antimicrobial effect and is indicated for use in dermatovenereology. Ural Scientific Research Institute of Dermatovenerology and Immunopathology has scheduled a study of using povidone-iodine solution in patients with urogenital infectious and inflammatory diseases in addition to the systemic treatment indicated for these diagnoses in accordance with current guidelines.