Is Plasma Total Antioxidant Capacity Elevated in Professional Soccer Athletes?: A Cross-Sectional Study

Owing to its ability to promote early recovery, platelet-rich plasma (PRP) is a popular regenerative therapy for treating sports injuries. However, its scientific basis has not yet been fully established. To bridge this gap, we focused on systemic antioxidant capacity, which suppresses exacerbated inflammation. Plasma total antioxidant capacity (TAC) in male professional soccer athletes (<i>n</i> = 30) was assessed alongside body composition measurements and compared with that of non-athletes (<i>n</i> = 31). Metabolic and inflammatory conditions were examined using erythrocyte sedimentation rate and plasma lactate, glucose, and protein levels. TAC levels were similar in both groups. Moderate correlations were observed between TAC and body fat percentage, skeletal muscle percentage, and basal metabolic rate in the control group, but not in the pro-athlete group, which exhibited superior body composition indices. These findings suggest that TAC levels may not directly influence PRP therapy in athletes. However, when compared with TAC levels calculated using correlations obtained in controls, the measured TAC levels (329.3 mM) were substantially higher than the compensated levels (62.5 mM for basal metabolic rate) in pro-athletes. This analytical approach indicates that TAC may theoretically be elevated to higher levels in pro-athletes when evaluated using non-athlete-based scales.