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Vanishing Lung Syndrome (VLS) is a rare, severe form of bullous pulmonary disease characterized by giant bullae occupying more than 30% of the hemithorax, which can easily be misdiagnosed as a pneumothorax. While cigarette smoking is the primary cause, other factors such as Ehlers-Danlos Syndrome and alpha-1 antitrypsin deficiency have also been associated with the condition. Surgical management, including pneumonectomy, remains the gold standard for severe VLS cases. This case report aims to highlight the effectiveness of the robotic approach and the benefits of robotic-assisted left pneumonectomy to treat VLS. Given that conservative management failed to improve this patient's symptoms, a robotic-assisted pneumonectomy was performed, offering precise dissection and faster recovery compared to traditional open thoracotomy or video-assisted thoracoscopic surgery (VATS). Four robotic ports, along with an assistant port, were utilized to gain access to the left chest. Dissection proceeded by dividing the inferior pulmonary ligament and then the pulmonary hilum, followed by the division of the inferior pulmonary vein and the left main bronchus in a sequential order to complete the pneumonectomy safely. The air leak test was negative, and the specimen was removed via the assistant port. Postoperative recovery was uneventful, and the patient was discharged on postoperative day 3. This robotic-assisted surgery offers smaller incisions via a five-incision approach, enhanced visualization, and reduced morbidity, making it a promising option for the management of VLS. This protocol is purposed to demonstrate a robotic-assisted pneumonectomy technique for VLS and its benefits. Nevertheless, further studies are needed to assess long-term outcomes and confirm the role of minimally invasive techniques in treating this rare condition.