Asporin Improves Cardiac Myocyte Response to Ischemia and Reperfusion Stress

20260 citationsJournal Articlegreen Open Access

Authors

Deepika Rai · Cedars-Sinai Smidt Heart Institute

Mukta Basu · Cedars-Sinai Medical Center

Liam McCarthy · Cedars-Sinai Smidt Heart Institute

Divya Gupta · Cedars-Sinai Smidt Heart Institute

Ashley Dinh · Cedars-Sinai Smidt Heart Institute

Matthew Ayres · Cedars-Sinai Smidt Heart Institute

Ajay Bhardwaj

Abstract

Our H/R model simulates key aspects of MI and R/I. The protective role of ASPN observed in this model suggests it as a promising candidate for developing cardioprotective therapies to minimize R/I and adverse cardiac-remodeling following MI.

Topics & Keywords

Cardiac Fibrosis and Remodeling Autophagy in Disease and Therapy Cardiac Ischemia and Reperfusion

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.01.22.701197

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