Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle

20261 citationsJournal Articlehybrid Open Access

Authors

Mubaraq A Toriola · University of Wisconsin–Milwaukee

Emma Timlin · University of Wisconsin–Milwaukee

Sarojini Bulbule · Milwaukee School of Engineering

Amy Reyes · Milwaukee School of Engineering

Omolola Mary Adedeji · University of Wisconsin–Milwaukee

C Gunnar Gottschalk · Sierra Nevada College

Animesh Barua

Abstract

Our study shows that impaired ATG13-driven autophagy increases inflammation through sirtuin-1 inactivation and NF-κB activation, suggesting a role for ATG13 in post-exertional malaise (PEM).

Topics & Keywords

Autophagy in Disease and Therapy Immune cells in cancer Amyotrophic Lateral Sclerosis Research

Publication Details

Published in: Inflammation Research

Volume 75, Issue 1, pp. 26-26

DOI: 10.1007/s00011-025-02158-6

Field-Weighted Citation Impact: 33.35

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Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle

Authors

Abstract

Topics & Keywords

Publication Details