Peculiarities of the morphological picture of chronic gastritis in the conditions of the north

For a comprehensive study of chronic gastritis’ endoscopic and morphological features with the development of precancerous changes of gastric mucosa CG Hp (+) and CG Hp (-) patients living permanently or temporarily in Yakutia were examined. The study was conducted based on a data from the Republican Hospital No. 1 - the National Center of Medicine of the Republic of Sakha (Yakutia). Some notable features of the morphologic pattern of chronic gastritis HP-negative and HP-positive are noted during the study. In patients with Helicobacter pylori identified during cytological examination, the degree of activity of the inflammatory process of the gastric mucosa during chronic gastritis was more pronounced and was accompanied by severe medical disorders in Yakutian conditions. Metaplastic changes in the gastric mucosa can be attributed to chronic gastritis of an infectious helicobacter nature, and these changes demonstrate profound violations of the processes of regeneration and differentiation of the gastric epithelium, metaplasia, mucosal atrophy, and dysplasia of the 1st and 2nd degrees. Patients with severe forms of chronic gastritis (with symptoms such as mucosal atrophy, intestinal metaplasia) have accounted for a larger percentage of patients from the studied group. Based on the obtained data, in patients with Helicobacter pylori established by cytological examination, the degree of activity of the inflammatory process of the gastric mucosa was more pronounced and was accompanied by severe disorders during CG in Yakutia.