GTX-11 attenuates lung fibrosis, inflammation and vascular remodeling in preclinical models of lung fibrotic disease

20260 citationsJournal Articlegold Open Access

Authors

Ana Montes-Worboys · Bellvitge University Hospital

Javier Milara · Centre for Biomedical Network Research on Rare Diseases

Consol Farrera · Gamma Therapeutics (United States)

Cristina Fernández-Asensio · Gamma Therapeutics (United States)

Silvia Sánchez-Díez · Gamma Therapeutics (United States)

Jaume Mercadé · Gamma Therapeutics (United States)

Paula Montero

Abstract

Altogether, our studies reveal that GTX-11 is an effective antifibrotic both <i>in vivo</i> and <i>in vitro</i>, suggesting that GTX-11 has potential as a therapeutic option for fibrotic ILDs.

Topics & Keywords

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Lung Cancer Treatments and Mutations Studies on Chitinases and Chitosanases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Pharmacology

Volume 16, pp. 1671132-1671132

DOI: 10.3389/fphar.2025.1671132

Field-Weighted Citation Impact: 0.00