Effect of storage conditions on NSE, S100, and B2M stability in cerebrospinal fluid and serum

20260 citationsJournal Article

Authors

Natalia García-Sancha · Hospital Universitario de Burgos

Juan Valencia · Hospital Universitario de Burgos

Simón Gundín · Hospital Universitario de Burgos

María Martín · Hospital Universitario de Burgos

María Miranda · Hospital Universitario de Burgos

Anna Valls · Hospital Sant Joan de Déu Barcelona

Sara Calvo-Simal

Abstract

CSF biomarkers NSE and S100 are highly susceptible to degradation at -20 °C, whereas B2M remains relatively stable. Strict adherence to -80 °C storage protocols is essential to ensure the reliability of biomarker-based diagnostics and research.

Topics & Keywords

S100 Proteins and Annexins Traumatic Brain Injury and Neurovascular Disturbances Cerebrospinal fluid and hydrocephalus

UN Sustainable Development Goals

Industry, innovation and infrastructure

Publication Details

Published in: Clinical Chemistry and Laboratory Medicine (CCLM)

DOI: 10.1515/cclm-2025-1320

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