Predictive value of seizure onset for gross motor dysfunction in individuals with pathogenic <i>GABRB2</i> and <i>GABRB3</i> variants

We found a clear genotype-phenotype correlation in GABRB2- and GABRB3-related disorders, demonstrating that GoF variants are associated with a more severe neurodevelopmental trajectory. The age at seizure onset serves as a biomarker for predicting motor outcomes in individuals with GoF variants. These findings provide guidance regarding prognosis, need for early intervention, and data for comparison of efficacy in targeted therapeutic interventions for GABA_A receptor-related disorders.