Zeb2os Hinders Cardiac Healing by Suppressing ZEB2 Reactivation and Cardiomyocyte Dedifferentiation

20261 citationsJournal Articlegreen Open Access

Authors

Rocco Caliandro · Amsterdam University Medical Centers

Merel L. Ligtermoet · Amsterdam University Medical Centers

Alexandra E. Giovou · Amsterdam University Medical Centers

Azra Husetić · Leiden University Medical Center

Arnie Boender · John Benjamins Publishing Company (Netherlands)

Huiling Zhou · Amsterdam University Medical Centers

Jermo Hanemaaijer-van der Veer

Abstract

Our findings identify Zeb2os as a stress-responsive inhibitor of ZEB2 reactivation that limits cardiomyocyte plasticity and hinders repair following ischemic injury. Given its specific activity under ischemic conditions, targeting Zeb2os may represent a novel therapeutic strategy to enhance endogenous cardiac regeneration.

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Publication Details

Published in: Circulation Research

Volume 138, Issue 5, pp. e327212-e327212

DOI: 10.1161/circresaha.125.327212

Field-Weighted Citation Impact: 25.01

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<i>Zeb2os</i> Hinders Cardiac Healing by Suppressing ZEB2 Reactivation and Cardiomyocyte Dedifferentiation

Authors

Abstract

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Publication Details