AI-assisted fibrosis scoring in MASH: Exploring pathologist decision-making with an SHG-based AI digital pathology tool

AI-powered digital pathology (AI-DP) as a pathologist's assistance tool can be utilized to improve pathologist concordance. However, pathologist judgement remains critical. In this study, we evaluated how pathologists used the assistance tool and how the platform impacted their decision-making. The findings are significant for pathologists and clinical researchers as they provide guidance for the well-informed use of SHG-based AI-DP as a tool to aid pathologists in fibrosis scoring in metabolic dysfunction-associated steatohepatitis. The insights gained can further inform policymakers about the integration of AI technologies in clinical trials or pathology workflows in clinical practice, promoting standardized practices.