Hemophilia Severity and Its Association With Mental Health and Health‐Related Quality of Life—Results From a Cross‐Sectional Multicenter Study

Major treatment advances have transformed hemophilia care, allowing most people with hemophilia (PwH) to have average lifespans. Reduced bleeding complications have shifted attention to overall well-being and mental health of PwH. The multicenter Swiss HERMES study examined 164 children and adults with hemophilia to explore the link between disease severity, treatment regimen, mental health, and health-related quality of life using standard questionnaires and a psychiatric interview. About one in four participants had at least one mental disorder-most often depression, substance use disorders, or ADHD. Participants with moderate or severe hemophilia, or lower clotting factor levels, reported poorer health-related quality of life. Prophylactic treatment may support mental health in participants with moderate or severe hemophilia. These findings show that mental health issues are common in PwH and highlight the need to integrate psychological screening and support into comprehensive hemophilia care.