Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson’s disease

This is the first tractography study to evaluate connectivity between the caudate nuclei and different frontal lobe regions, unveiling specific white matter alterations in early Parkinson's disease. Our findings suggest that caudate atrophy, though not directly correlated with clinical variables, may underlie or result from impaired caudate-cortical connectivity, potentially accounting for some of the multifaceted PD symptoms.