Electrical or magnetic nerve stimulation enhance the BoNT/A-mediated muscle paralysis

We established an electrical and a magnetic nerve stimulation protocol combined with BoNT/A treatment in mice. Combination of i.m. BoNT/A injection with TENS or MS demonstrated an enhanced BoNT/A effect as compared to non-stimulated groups. Despite limitations of the magnetic stimulation method in the mouse our data revives the discussion of BoNT/A effect augmentation by stimulating the injected muscles' efferent nerves during the BoNT/A uptake phase.